Control of blood pressure in liver transplant recipients

Transplantation. 2012 May 27;93(10):1031-7. doi: 10.1097/TP.0b013e31824cd5e6.

Abstract

Background: Increased blood pressure (BP) is common after liver transplantation. However, there is scarce information on its control.

Methods: In this prospective, cross-sectional, multicenter study, we determined BP according to the recommended international standards in 921 liver transplant patients during one routine outpatient visit to assess their grade of control of BP. At the time of the study, 490 patients had been previously diagnosed with arterial hypertension and were receiving antihypertensive treatment, and 431 were not previously diagnosed as hypertensive.

Results: In the hypertensive group, arterial hypertension was uncontrolled (BP >140/90 mm Hg [>130/80 in diabetics]) in 158 (32%) patients and controlled in 332 (68%) patients. In a multivariate analysis, only diabetes was identified as a significant predictor of uncontrolled hypertension. Among patients not previously diagnosed as hypertensive, BP was increased in 106 (25%) and normal in 325 (75%). On multivariate analysis, the only variable independently associated with increased BP in this group was metabolic syndrome.

Conclusion: BP is not adequately controlled in a noticeable percentage of liver transplant patients, especially in subjects with diabetes or metabolic syndrome.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Pressure*
  • Calcineurin Inhibitors
  • Cross-Sectional Studies
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Liver Transplantation*
  • Male
  • Middle Aged
  • Prospective Studies

Substances

  • Calcineurin Inhibitors