Clozapine-induced stuttering: a case report and analysis of similar case reports in the literature

Gen Hosp Psychiatry. 2012 Nov-Dec;34(6):703.e1-3. doi: 10.1016/j.genhosppsych.2012.02.010. Epub 2012 Apr 18.

Abstract

There is limited literature reporting clozapine-associated stuttering. In this case report, we present a case of a young male who developed stuttering with clozapine, which improved with dose reduction. Computer-assisted searches on clozapine-induced stuttering yielded 16 cases, and analysis of these case reports suggests that stuttering may be linked to seizures or movement disorders, but other putative mechanisms may be at work, which need further research.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects*
  • Clozapine / adverse effects*
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Movement Disorders / etiology
  • Schizophrenia / drug therapy*
  • Seizures / chemically induced
  • Stuttering / chemically induced*

Substances

  • Antipsychotic Agents
  • Clozapine