Portal hypertension in children

Chiara Grimaldi; Jean de Ville de Goyet; Valerio Nobili

doi:10.1016/j.clinre.2012.03.016

Portal hypertension in children

Clin Res Hepatol Gastroenterol. 2012 Jun;36(3):260-1. doi: 10.1016/j.clinre.2012.03.016. Epub 2012 Apr 21.

Authors

Chiara Grimaldi¹, Jean de Ville de Goyet, Valerio Nobili

Affiliation

¹ Department of Paediatric Surgery and Transplantation Center, Bambino Gesù Childrens Hospital, Roma, Italy.

PMID: 22521554
DOI: 10.1016/j.clinre.2012.03.016

Abstract

The main causes of intrahepatic portal hypertension in children are cirrhosis and congenital hepatic fibrosis. Non cirrhotic portal hypertension in children is mostly due to extrahepatic portal vein obstruction. In half of cases, no underlying disorder is found. The meso-Rex bypass is the preferred treatment, when it is possible. The closest to the portal vein the obstruction, the highest the risk of esophagogastric varices.

MeSH terms

Child
Endoscopy, Digestive System
Esophageal and Gastric Varices / etiology
Esophageal and Gastric Varices / surgery
Humans
Hypertension, Portal / diagnosis
Hypertension, Portal / etiology*
Hypertension, Portal / therapy*
Liver Cirrhosis / surgery
Liver Transplantation
Portal Vein / diagnostic imaging
Portal Vein / surgery
Portasystemic Shunt, Surgical
Propranolol / administration & dosage
Ultrasonography, Doppler
Vascular Diseases / complications
Vascular Diseases / surgery
Vasodilator Agents / administration & dosage

Substances

Vasodilator Agents
Propranolol