Abstract
Eraserhead: Stem cells seem to erase epigenetic information by decarboxylation of the newly discovered epigenetic base 5-carboxycytosine (caC; see picture). This reaction is likely to involve a nucleophilic attack of the C5-C6 double bond.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Cytosine / analogs & derivatives*
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Cytosine / chemistry
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Cytosine / metabolism
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DNA / chemistry
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Decarboxylation
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Embryonic Stem Cells / chemistry*
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Embryonic Stem Cells / metabolism
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Mice
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Nitrogen Isotopes / chemistry
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Oxidation-Reduction
Substances
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5-carboxylcytosine
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Nitrogen Isotopes
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Cytosine
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DNA