Abstract
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the antileukemic agent mezerein are diterpene esters of plant origin with certain structural similarities. Both compounds, when applied topically to mouse skin, were equipotent on a molar basis in inducing hyperplasia, inflammation, and ornithine decarboxylase activity, as well as in reducing cyclic adenosine 3':5'-monophosphate accumulation in response to beta-adrenergic stimulation. In contrast, mezerein was much less effective as a tumor promoter; the phorbol ester at 8.5 nmol/application yielded 78-fold more tumors than did 8.5 nmol mezerein per application to similarly initiated SENCAR mice. The superiority of the phorbol ester was nearly as great in CD-1 mice.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / toxicity*
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Cell Division / drug effects
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Cyclic AMP / metabolism
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Dermatitis, Contact
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Diterpenes
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Female
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Isoproterenol / pharmacology
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Mice
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Neoplasms, Experimental / chemically induced
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Ornithine Decarboxylase / biosynthesis
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Papilloma / chemically induced*
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Phorbol Esters / toxicity*
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Phorbols / toxicity*
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Skin / drug effects*
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Skin / metabolism
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Skin Neoplasms / chemically induced*
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Tetradecanoylphorbol Acetate / toxicity*
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Phorbol Esters
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Phorbols
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mezerein
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Cyclic AMP
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Ornithine Decarboxylase
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Isoproterenol
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Tetradecanoylphorbol Acetate