Dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its gene polymorphisms are associated with sepsis prognosis

Inflammation. 2012 Dec;35(6):1833-43. doi: 10.1007/s10753-012-9504-z.

Abstract

This study explored the association of sepsis prognosis with dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its polymorphisms. We enrolled 80 subjects with sepsis and 80 controls. Serum sTREM-1 was tested on days 1, 3, 5, 7, 10, and 14. PCR sequencing was performed to detect TREM-1 genetic variation on its four exons. sTREM-1 levels were significantly higher in the nonsurvivor than in the survivor group (p < 0.001), and those at each time point were the same (p ≤ 0.001). Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). However, there was no relationship between TREM-1 polymorphism and dynamic concentration of sTREM-1. Logistic regression showed that sTREM-1, APACHE II, and rs2234237 polymorphism are risk factors for prognosis. Dynamic changes in serum sTREM-1 and rs2234237 polymorphism could be used in sepsis prognosis assessment.

Trial registration: ClinicalTrials.gov NCT01490424.

Publication types

  • Clinical Trial

MeSH terms

  • Biomarkers / blood
  • Female
  • Genetic Variation
  • Humans
  • Male
  • Membrane Glycoproteins / blood*
  • Membrane Glycoproteins / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Prognosis
  • Receptors, Immunologic / blood*
  • Receptors, Immunologic / genetics*
  • Risk Factors
  • Sepsis / blood*
  • Sepsis / genetics*
  • Sepsis / mortality
  • Triggering Receptor Expressed on Myeloid Cells-1

Substances

  • Biomarkers
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM1 protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1

Associated data

  • ClinicalTrials.gov/NCT01490424