Abstract
DiGeorge syndrome is associated with a T-lymphocyte immunodeficiency. The prevalence of hypogammaglobulinemia has not been reported. We found that 3% of patients with DiGeorge syndrome were receiving immunoglobulin replacement therapy and 6% of patients over the age of 3 years had hypogammaglobulinemia. We conclude that DiGeorge syndrome is associated with significant humoral immune deficiency.
Copyright © 2012 Mosby, Inc. All rights reserved.
MeSH terms
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Adolescent
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Adult
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B-Lymphocytes / cytology*
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Child
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Child, Preschool
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Cohort Studies
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DiGeorge Syndrome / diagnosis*
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DiGeorge Syndrome / genetics
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Europe
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Humans
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IgA Deficiency / blood
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IgA Deficiency / diagnosis*
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Immunoglobulin A / metabolism
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Immunoglobulin G / metabolism
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Immunoglobulin M / metabolism
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Immunoglobulins / metabolism
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Infant
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Infant, Newborn
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Middle Aged
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Prevalence
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Registries
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T-Lymphocytes / cytology
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United States
Substances
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Immunoglobulin A
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Immunoglobulin G
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Immunoglobulin M
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Immunoglobulins