Abstract
Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antiviral Agents / pharmacology*
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Drug Resistance, Viral / genetics
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Humans
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Influenza A Virus, H1N1 Subtype / drug effects*
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Influenza A Virus, H1N1 Subtype / genetics
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Influenza A Virus, H1N1 Subtype / isolation & purification
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Influenza, Human / diagnosis
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Influenza, Human / drug therapy
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Influenza, Human / virology*
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Molecular Sequence Data
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Mutation
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Netherlands
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Neuraminidase / genetics
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Oseltamivir / pharmacology*
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Sentinel Surveillance
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Spain
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Travel*
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Treatment Outcome
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Young Adult
Substances
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Antiviral Agents
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Oseltamivir
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Neuraminidase