Fatal outcome after heart transplantation caused by Aspergillus lentulus

Transpl Infect Dis. 2012 Oct;14(5):E60-3. doi: 10.1111/j.1399-3062.2012.00779.x. Epub 2012 Sep 19.

Abstract

Opportunistic invasive fungal infections are a major cause of mortality in immunocompromised patients. Early diagnosis of invasive aspergillosis and proper identification of the causative agent is crucial for guidance of therapy. Accurate differentiation of Aspergillus lentulus, a filamentous fungus often misidentified as atypical Aspergillus fumigatus, is of concern as multiple antifungal drugs show a reduced susceptibility. This is the first report, to our knowledge, of a proven pulmonary invasive fungal infection caused by A. lentulus after heart transplantation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antifungal Agents / therapeutic use
  • Aspergillus / classification
  • Aspergillus / isolation & purification*
  • Fatal Outcome
  • Heart Transplantation / adverse effects*
  • Humans
  • Immunocompromised Host
  • Invasive Pulmonary Aspergillosis / drug therapy
  • Invasive Pulmonary Aspergillosis / microbiology*
  • Male
  • Opportunistic Infections / drug therapy
  • Opportunistic Infections / microbiology*

Substances

  • Antifungal Agents