Abstract
We investigated the frequency and clinical significance of macrolide resistance in adult and pediatric patients with community-acquired pneumonia from a Mycoplasma pneumoniae infection. The frequency of the A2063G mutation in the 23S rRNA gene was significantly higher in children than in adults (61.3% [19/31] and 13.3% [8/60], respectively; P < 0.001). Patients with macrolide-resistant M. pneumoniae infections showed a longer duration of fever (P = 0.021) and required a longer duration of antibiotic treatment (P = 0.007).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Child
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Child, Preschool
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Community-Acquired Infections / drug therapy
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Community-Acquired Infections / genetics*
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Community-Acquired Infections / microbiology*
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DNA / genetics
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Drug Resistance, Bacterial / genetics*
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Female
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Humans
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Infant
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Macrolides / pharmacology*
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Macrolides / therapeutic use
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mutation
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Mycoplasma pneumoniae / drug effects*
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Mycoplasma pneumoniae / genetics*
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Nasopharynx / microbiology
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Pneumonia, Mycoplasma / drug therapy
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Pneumonia, Mycoplasma / genetics*
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Pneumonia, Mycoplasma / microbiology*
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Polymerase Chain Reaction
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RNA, Ribosomal, 23S / genetics*
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Young Adult
Substances
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Anti-Bacterial Agents
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Macrolides
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RNA, Ribosomal, 23S
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DNA