Imaging acidosis in tumors using a pH-activated near-infrared fluorescence probe

Chem Commun (Camb). 2012 Dec 11;48(95):11677-9. doi: 10.1039/c2cc36488c.

Abstract

A novel pH activatable near-infrared fluorescence probe was developed, which successfully visualized acidosis in tumors. This probe holds promise to non-invasively predict the tumor metastasis potential and evaluate the therapeutic response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acidosis / pathology*
  • Animals
  • Carbocyanines / chemical synthesis
  • Carbocyanines / chemistry*
  • Cell Line, Tumor
  • Fluorescent Dyes / chemistry*
  • Humans
  • Hydrazones / chemical synthesis
  • Hydrazones / chemistry*
  • Hydrogen-Ion Concentration
  • Kinetics
  • Lysosomes / chemistry
  • Lysosomes / metabolism
  • Mice
  • Mice, Nude
  • Microscopy, Fluorescence
  • Neoplasms / pathology
  • Spectroscopy, Near-Infrared
  • Transplantation, Heterologous

Substances

  • Carbocyanines
  • DiIR783-S
  • Fluorescent Dyes
  • Hydrazones