Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain

J Clin Microbiol. 2013 Jan;51(1):356-9. doi: 10.1128/JCM.02247-12. Epub 2012 Oct 24.

Abstract

A neonate with herpes simplex virus 1 encephalitis was treated with intravenous acyclovir. During the course of therapy, the infection became intractable to the treatment and a mutation in the viral thymidine kinase gene (nucleotide G375T, amino acid Q125H) developed. This mutation was demonstrated in vitro to confer acyclovir resistance.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / pharmacology*
  • Acyclovir / therapeutic use
  • Amino Acid Substitution
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • DNA, Viral / chemistry
  • DNA, Viral / genetics
  • Drug Resistance, Viral*
  • Encephalitis, Herpes Simplex / diagnosis*
  • Encephalitis, Herpes Simplex / virology
  • Herpes Simplex / diagnosis*
  • Herpes Simplex / virology
  • Herpesvirus 1, Human / drug effects
  • Herpesvirus 1, Human / genetics
  • Herpesvirus 1, Human / isolation & purification*
  • Humans
  • Infant, Newborn
  • Male
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Mutation, Missense
  • Pregnancy Complications, Infectious / diagnosis*
  • Pregnancy Complications, Infectious / virology
  • Sequence Analysis, DNA
  • Thymidine Kinase / genetics

Substances

  • Antiviral Agents
  • DNA, Viral
  • Thymidine Kinase
  • Acyclovir

Supplementary concepts

  • Neonatal herpes

Associated data

  • GENBANK/AB713519
  • GENBANK/AB713520