Abstract
A neonate with herpes simplex virus 1 encephalitis was treated with intravenous acyclovir. During the course of therapy, the infection became intractable to the treatment and a mutation in the viral thymidine kinase gene (nucleotide G375T, amino acid Q125H) developed. This mutation was demonstrated in vitro to confer acyclovir resistance.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / pharmacology*
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Acyclovir / therapeutic use
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Amino Acid Substitution
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Antiviral Agents / pharmacology*
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Antiviral Agents / therapeutic use
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DNA, Viral / chemistry
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DNA, Viral / genetics
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Drug Resistance, Viral*
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Encephalitis, Herpes Simplex / diagnosis*
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Encephalitis, Herpes Simplex / virology
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Herpes Simplex / diagnosis*
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Herpes Simplex / virology
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Herpesvirus 1, Human / drug effects
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Herpesvirus 1, Human / genetics
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Herpesvirus 1, Human / isolation & purification*
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Humans
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Infant, Newborn
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Male
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation, Missense
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Pregnancy Complications, Infectious / diagnosis*
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Pregnancy Complications, Infectious / virology
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Sequence Analysis, DNA
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Thymidine Kinase / genetics
Substances
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Antiviral Agents
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DNA, Viral
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Thymidine Kinase
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Acyclovir
Associated data
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GENBANK/AB713519
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GENBANK/AB713520