Abstract
A 23-week-old baby, born at 26(+2) weeks, presented to the hospital with critical respiratory failure, which was impossible to stabilize. She had unstable oxygen saturations between 35% and 95%. A presumptive diagnosis of bronchopulmonary dysplasia with associated pulmonary hypertensive crisis was made. In the absence of inhaled nitric oxide, 2 oral doses of 1 mg/kg sildenafil were given, with a dramatic improvement 30 to 45 minutes later. Her oxygenation index fell from 43 to 14. She made a full recovery and was discharged from the hospital 2 weeks later.
MeSH terms
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Administration, Oral
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Bronchopulmonary Dysplasia / blood
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Bronchopulmonary Dysplasia / complications
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Bronchopulmonary Dysplasia / diagnosis
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Heart Arrest / blood
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Heart Arrest / etiology
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Humans
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Hypertension, Pulmonary / blood
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Hypertension, Pulmonary / diagnosis
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Hypertension, Pulmonary / drug therapy*
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Infant
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Infant, Newborn
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Infant, Premature, Diseases / blood
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Infant, Premature, Diseases / diagnosis
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Infant, Premature, Diseases / drug therapy*
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Intensive Care Units, Neonatal
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Intubation, Gastrointestinal
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Oxygen / blood
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Phosphodiesterase 5 Inhibitors / administration & dosage*
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Phosphodiesterase 5 Inhibitors / adverse effects
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Piperazines / administration & dosage*
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Piperazines / adverse effects
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Purines / administration & dosage
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Purines / adverse effects
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Respiratory Insufficiency / blood
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Respiratory Insufficiency / diagnosis
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Respiratory Insufficiency / drug therapy*
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Sildenafil Citrate
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Sulfones / administration & dosage*
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Sulfones / adverse effects
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Vasodilator Agents / administration & dosage*
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Vasodilator Agents / adverse effects
Substances
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Phosphodiesterase 5 Inhibitors
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Piperazines
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Purines
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Sulfones
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Vasodilator Agents
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Sildenafil Citrate
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Oxygen