A meta-analysis about the association between -1082G/A and -819C/T polymorphisms of IL-10 gene and risk of type 2 diabetes

Abstract

The present meta-analysis was conducted to investigate the association between the -1082G/A and -819C/T polymorphisms of the IL-10 gene and risk of type 2 diabetes mellitus (T2DM). Relevant articles were identified by searching PubMed, Embase, and Web of Science. Pooled odds ratios (ORs) were used to assess the strength of the association between target polymorphisms and the risk of T2DM. Significant associations between the -1082G/A polymorphism and T2DM were found for the allele contrast (OR=0.90, 95% CI: [0.83, 0.98], P=0.02), homozygote contrast (OR=0.82, 95% CI: [0.69, 0.97], P=0.02), and recessive genetic model (OR=0.85, 95% CI: [0.74, 0.96], P=0.01). However, no significant association was found for the dominant genetic model (OR=0.91, 95% CI: [0.80, 1.05], P=0.08). The association between -819C/T polymorphism and T2DM was significant for the allele contrast (OR=0.73, 95% CI: [0.64, 0.84], P<0.01); however, no significant associations were found for -819C/T in the homozygote contrast (OR=1.01, 95% CI: [0.38, 2.67], P=0.99), dominant genetic model (OR=0.94, 95% CI: [0.50, 1.77], P=0.86), and recessive genetic model (OR=0.92, 95% CI: [0.50, 1.68], P=0.78). No significant publication bias was detected. This meta-analysis suggests that allele A of -1082G/A and allele C of -819C/T in the IL-10 gene have potentially protective effects in terms of risk of T2DM.