Pharmacological inhibition of stearoyl CoA desaturase in the skin induces atrophy of the sebaceous glands

J Invest Dermatol. 2013 Aug;133(8):2091-4. doi: 10.1038/jid.2013.89. Epub 2013 Feb 27.
No abstract available

Publication types

  • Letter

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / enzymology
  • Acne Vulgaris / pathology
  • Animals
  • Atrophy
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Hep G2 Cells
  • Humans
  • Mice
  • Mice, Inbred Strains
  • Piperazines / chemistry
  • Piperazines / pharmacology*
  • Pyridazines / chemistry
  • Pyridazines / pharmacology*
  • Sebaceous Glands / drug effects*
  • Sebaceous Glands / enzymology
  • Sebaceous Glands / pathology
  • Skin / drug effects*
  • Skin / pathology
  • Stearoyl-CoA Desaturase / antagonists & inhibitors*
  • Stearoyl-CoA Desaturase / metabolism

Substances

  • 6-(4-(5-fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl)pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide
  • Enzyme Inhibitors
  • Piperazines
  • Pyridazines
  • Stearoyl-CoA Desaturase