CTX-M-55-type extended-spectrum β-lactamase-producing Shigella sonnei isolated from a Korean patient who had travelled to China

Ann Lab Med. 2013 Mar;33(2):141-4. doi: 10.3343/alm.2013.33.2.141. Epub 2013 Feb 21.

Abstract

We report a case of CTX-M-55-type extended-spectrum β-lactamase (ESBL)-producing Shigella sonnei infection in a 27-year-old Korean woman who had traveled to China. The patient was admitted to the hospital due to abdominal pain, watery diarrhea, and fever (39.3℃). S. sonnei was isolated from her stool specimens, and the pathogen was found to be resistant to cefotaxime due to CTX-M-55-type ESBL. Insertion sequence (IS)Ecp1 was found upstream of the blaCTX-M-55 gene. The blaCTX-M-55 gene was transferred from the S. sonnei isolate to an Escherichia coli J53 recipient by conjugation. Pulsed-field gel electrophoresis and Southern blotting revealed that the blaCTX-M-55 gene was located on a plasmid of approximately 130 kb.

Keywords: CTX-M-55; ESBL; Shigella sonnei.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Asian People
  • Cefotaxime / pharmacology
  • China
  • Drug Resistance, Bacterial / drug effects
  • Dysentery, Bacillary / diagnosis
  • Dysentery, Bacillary / microbiology*
  • Electrophoresis, Gel, Pulsed-Field
  • Escherichia coli / metabolism
  • Feces / microbiology
  • Female
  • Humans
  • Plasmids / chemistry
  • Plasmids / genetics
  • Republic of Korea
  • Shigella sonnei / enzymology
  • Shigella sonnei / isolation & purification*
  • Travel
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases
  • Cefotaxime