Acquisition of carbapenem resistance in multiresistant Klebsiella pneumoniae isolates of sequence type 11 at a university hospital in China

Diagn Microbiol Infect Dis. 2013 Jun;76(2):241-3. doi: 10.1016/j.diagmicrobio.2013.02.002. Epub 2013 Mar 19.

Abstract

Four closely related KPC-producing Klebsiella pneumoniae strains, which were isolated from the patients with neonatal sepsis, harbored bla(CTX-M-14), bla(TEM-1), bla(CTX-M-15), bla(SHV-11),bla(SHV-12), class 1 integron, qnrS1, acc(6')-Ib-cr, and rmtB genes. Multilocus sequence typing experiments showed that all isolates but Kp122 were proven to share the same sequence type (ST), ST11. These isolates have not yet been previously reported in a university-affiliated children's hospital or in the city of Wenzhou.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / pharmacology*
  • China
  • DNA, Bacterial / isolation & purification
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Gene Transfer, Horizontal
  • Genes, Bacterial
  • Hospitals, University
  • Humans
  • Infant
  • Integrons
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / isolation & purification
  • Multilocus Sequence Typing
  • Polymerase Chain Reaction
  • RNA, Ribosomal, 16S / isolation & purification
  • Sepsis / microbiology
  • Sepsis / pathology
  • Sequence Analysis, DNA

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • DNA, Bacterial
  • RNA, Ribosomal, 16S