Abstract
Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Blood-Brain Barrier / drug effects
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Blood-Brain Barrier / physiopathology*
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Brain / pathology*
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Cell Line, Transformed
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Cytokines / metabolism
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Endothelial Cells / drug effects
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Endothelial Cells / metabolism
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Endothelial Cells / physiology*
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Gene Expression Regulation / drug effects
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Genetic Vectors / physiology
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Humans
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Inflammation / pathology*
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MicroRNAs / genetics
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MicroRNAs / metabolism*
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Multiple Sclerosis / pathology*
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RNA, Small Interfering / pharmacology
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Transendothelial and Transepithelial Migration / drug effects
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Transfection
Substances
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Cytokines
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MicroRNAs
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RNA, Small Interfering