Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis

M Jonges; A Meijer; R A Fouchier; G Koch; J Li; J C Pan; H Chen; Y L Shu; M P Koopmans

Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis

Euro Surveill. 2013 Apr 18;18(16):20460.

Authors

M Jonges¹, A Meijer, R A Fouchier, G Koch, J Li, J C Pan, H Chen, Y L Shu, M P Koopmans

Affiliation

¹ Department of Virology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. marcel.jonges@rivm.nl

PMID: 23611030

Abstract

The recently identified human infections with avian influenza A(H7N9) viruses in China raise important questions regarding possible source and risk to humans. Sequence comparison with an influenza A(H7N7) outbreak in the Netherlands in 2003 and an A(H7N1) epidemic in Italy in 1999–2000 suggests that widespread circulation of A(H7N9) viruses must have occurred in China. The emergence of human adaptation marker PB2 E627K in human A(H7N9) cases parallels that of the fatal A(H7N7) human case in the Netherlands.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
China / epidemiology
Disease Outbreaks*
Humans
Influenza A Virus, H7N1 Subtype / genetics
Influenza A Virus, H7N1 Subtype / isolation & purification
Influenza A Virus, H7N7 Subtype / genetics
Influenza A Virus, H7N7 Subtype / isolation & purification
Influenza A virus / classification
Influenza A virus / genetics*
Influenza A virus / isolation & purification
Influenza in Birds / virology*
Influenza, Human / diagnosis
Influenza, Human / epidemiology*
Influenza, Human / virology*
Italy / epidemiology
Netherlands / epidemiology
Poultry
Sequence Analysis / methods*