[Prior infected influenza virus could protect mice from challenge of lethal influenza virus]

Li-Qi Liu; Zi Li; Yun Zhu; Yue-Long Shu

[Prior infected influenza virus could protect mice from challenge of lethal influenza virus]

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Dec;26(6):405-8.

[Article in Chinese]

Authors

Li-Qi Liu¹, Zi Li, Yun Zhu, Yue-Long Shu

Affiliation

¹ Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, WHO Collaborating Center for Reference and Research on Influenza, 155 Changbai Road, Bejing 102206, China.

PMID: 23627014

Abstract

Objective: To determine whether it could protect mice from challenge of lethal influenza virus which group prior infected A(H1N1) pdm09 and H9N2 virus respectively.

Methods: 150 BALB/c mice are divided into three groups. Mice are infected A(H1N1) pdm09 virus (pCA07) and poultry H9N2 virus (GZ333) respectively. Infected mice are challenged with 10 times of lethal dose virus (PR8) then compare the viral load, antibody and survival of the two group mice before and after challenged.

Results: Both experimental group mice survived after challenge of lethal influenza virus and lung viral load are lower than that of the first infection. Antibodies derived from the infective virus and challenge virus.

Conclusion: Prior infected A(H1N1) pdm09 and H9N2 virus could protect mice from challenge of lethal influenza virus.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Viral / immunology
Female
Humans
Influenza A Virus, H1N1 Subtype / physiology*
Influenza A Virus, H9N2 Subtype / physiology*
Influenza, Human / immunology
Influenza, Human / prevention & control*
Influenza, Human / virology*
Lung / immunology
Lung / virology
Mice
Mice, Inbred BALB C
Viral Load

Substances

Antibodies, Viral