Bacterial peritonitis due to Acinetobacter baumannii sequence type 25 with plasmid-borne new delhi metallo-β-lactamase in Honduras

Antimicrob Agents Chemother. 2013 Sep;57(9):4584-6. doi: 10.1128/AAC.00275-13. Epub 2013 Jul 1.

Abstract

A carbapenem-resistant Acinetobacter baumannii strain was isolated from the peritoneal fluid of a patient with complicated intra-abdominal infection and evaluated at the Multidrug-resistant Organism Repository and Surveillance Network by whole-genome sequencing and real-time PCR. The isolate was sequence type 25 and susceptible to colistin and minocycline, with low MICs of tigecycline. blaNDM-1 was located on a plasmid with >99% homology to pNDM-BJ02. The isolate carried numerous other antibiotic resistance genes, including the 16S methylase gene, armA.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acinetobacter Infections / diagnosis
  • Acinetobacter Infections / drug therapy
  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / enzymology
  • Acinetobacter baumannii / genetics
  • Acinetobacter baumannii / isolation & purification*
  • Aged
  • Anti-Bacterial Agents / pharmacology
  • Colistin / pharmacology
  • Drug Resistance, Multiple, Bacterial
  • High-Throughput Nucleotide Sequencing
  • Honduras
  • Humans
  • Male
  • Methyltransferases / genetics
  • Methyltransferases / metabolism
  • Minocycline / analogs & derivatives
  • Minocycline / pharmacology
  • Peritonitis / diagnosis
  • Peritonitis / drug therapy
  • Peritonitis / microbiology*
  • Plasmids*
  • Tigecycline
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Tigecycline
  • 16S rRNA - m7G methyltransferase
  • Methyltransferases
  • beta-Lactamases
  • beta-lactamase NDM-1
  • Minocycline
  • Colistin