Life-threatening infections in medically immunocompromised patients

Crit Care Clin. 2013 Oct;29(4):807-26. doi: 10.1016/j.ccc.2013.06.002. Epub 2013 Aug 12.

Abstract

Chronic medical diseases, such as diabetes, chronic obstructive pulmonary disease, chronic kidney disease, cirrhosis, and heart failure, are associated with various immune defects that make affected patients prone to specific infections. This review discusses the epidemiology, pathogenesis, antimicrobial and surgical management, supportive care, and outcome of life-threatening infections associated with common chronic medical diseases.

Keywords: Chronic kidney failure; Chronic obstructive pulmonary disease; Critical illness; Diabetes mellitus; Heart failure.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / therapeutic use*
  • Bacterial Infections / drug therapy
  • Bacterial Infections / etiology*
  • Bacterial Infections / immunology
  • Chronic Disease
  • Diabetes Complications / immunology
  • Diabetes Complications / therapy
  • Humans
  • Immunocompromised Host / physiology*
  • Pulmonary Disease, Chronic Obstructive / complications
  • Pulmonary Disease, Chronic Obstructive / drug therapy
  • Pulmonary Disease, Chronic Obstructive / immunology
  • Sepsis / mortality*

Substances

  • Anti-Infective Agents