Impact of unlabeled French antibiotic guidelines on antibiotic prescriptions for acute respiratory tract infections in 7 Pediatric Emergency Departments, 2009-2012

François Angoulvant; Miguel Pereira; Francis Perreaux; Valerie Soussan; Luu-Ly Pham; Thanh-Van Trieu; Bogdan Cojocaru; Romain Guedj; Robert Cohen; Corinne Alberti; Vincent Gajdos

doi:10.1097/INF.0000000000000125

Impact of unlabeled French antibiotic guidelines on antibiotic prescriptions for acute respiratory tract infections in 7 Pediatric Emergency Departments, 2009-2012

Pediatr Infect Dis J. 2014 Mar;33(3):330-3. doi: 10.1097/INF.0000000000000125.

Authors

François Angoulvant¹, Miguel Pereira, Francis Perreaux, Valerie Soussan, Luu-Ly Pham, Thanh-Van Trieu, Bogdan Cojocaru, Romain Guedj, Robert Cohen, Corinne Alberti, Vincent Gajdos

Affiliation

¹ From the *Hôpitaux de Paris (APHP), Pediatric Emergency Department, Hôpital Robert Debré and Université Paris 7 Denis Diderot, Paris; †Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Reproduction and Child Development Team, Villejuif; ‡Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Antoine Béclère and Université Paris 11, Clamart; §Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Ambroise Paré and Université Versailles-Saint-Quentin-en-Yvelines, Boulogne; ¶Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Bicêtre and Université Paris 11, Kremlin-Bicêtre; ‖Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Jean Verdier and Université Paris 13, Bondy; ††Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Louis Mourier and Université Paris 7 Denis Diderot, Colombes; ‡‡Hôpitaux de Paris (APHP), Pediatric Emergency Department, Hôpital Armand Trousseau and Université Paris 6 Descartes, Paris; §§Pediatric Department, Centre Hospitalier Intercommunal, Créteil; and ¶¶Hôpitaux de Paris (APHP), Clinical Epidemiologic Unit and INSERM CIE-5, Hôpital Robert Debré and Université Paris 7 Denis Diderot, Paris, France.

PMID: 24168976
DOI: 10.1097/INF.0000000000000125

Abstract

From November 2009 to October 2012, implementation of guidelines, unlabeled by the French Agency of Health Products, changed the categories of antibiotics prescribed for acute respiratory tract infections in 7 pediatric emergency departments. During the study, 36,413 acute respiratory tract infections-related antibiotic prescriptions were prescribed. Amoxicillin prescriptions rose from 30.0% to 84.7%, while amoxicillin-clavulanate and cefpodoxime prescriptions decreased to 10.2% and 2.5%, respectively.

Publication types

Observational Study

MeSH terms

Amoxicillin / administration & dosage
Amoxicillin / therapeutic use
Amoxicillin-Potassium Clavulanate Combination / administration & dosage
Amoxicillin-Potassium Clavulanate Combination / therapeutic use
Anti-Bacterial Agents / administration & dosage*
Anti-Bacterial Agents / therapeutic use*
Cefpodoxime
Ceftizoxime / administration & dosage
Ceftizoxime / analogs & derivatives
Ceftizoxime / therapeutic use
Child, Preschool
Drug Prescriptions / statistics & numerical data*
Drug Resistance, Bacterial
Emergency Service, Hospital / statistics & numerical data*
France
Humans
Infant
Pediatrics
Practice Guidelines as Topic
Prospective Studies
Respiratory Tract Infections / drug therapy*
Respiratory Tract Infections / epidemiology

Substances

Anti-Bacterial Agents
Amoxicillin-Potassium Clavulanate Combination
Amoxicillin
Ceftizoxime