Renal denervation (RDN) has been shown to be safe and efficacious in reducing blood pressure in patients with resistant hypertension. In the present study, we describe a first-in-man report of the Iberis renal denervation device in a patient who underwent two RDN procedures: one via the femoral artery and one via the transulnar approach. RDN was performed in the patient's right renal artery using an Iberis catheter via the transulnar approach, as the transfemoral or transradial arteries could not be approached due to their anatomic constraints. In summary, RDN via the transulnar approach is feasible and represents a technical alternative solution in certain patients.