In 2010 Dillard University and Louisiana State University Health Sciences Center in New Orleans collaborated to secure a five year-grant from the National Institute of Minority Health and Health Disparities of the National Institutes of Health to establish a Minority Health and Health Disparities Research Center (MHHDRC) located on the campus of Dillard University. The MHHDRC is the first Federally funded Center of Excellence in the state of Louisiana. Three cores of the Center operate to achieve its mission. One core includes a clinical research associate (CRA) training program. The major goal of the program is to increase the number of minority CRAs in the state of Louisiana, especially in New Orleans and, ultimately promote greater participation and retention of minorities in clinical trials research. This article discusses the initiation of the CRA training program, its planning, community outreach, implementation, integration of multiple resources and role of collaboration in the development of the MHHDRC including accomplishments, challenges and future plans.