Abstract
Interferon regulatory factor (IRF) regulation of the type I interferon response has not been extensively explored in murine retroviral infections. IRF-3(-/-) and select IRF-3/7(-/-) mice were resistant to LP-BM5-induced pathogenesis. However, further analyses strongly suggested that resistance could be attributed to strain 129-specific contamination of the known retrovirus resistance gene Fv1. Therefore, caution should be taken when interpreting phenotypes observed in these knockout mice, as strain 129-derived genetic polymorphisms may explain observed differences.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Disease Models, Animal*
-
Electrophoresis
-
Gammaretrovirus / genetics
-
Gammaretrovirus / immunology*
-
Interferon Regulatory Factor-3 / genetics*
-
Interferon Regulatory Factor-7 / genetics*
-
Interferon Type I / immunology*
-
Mice
-
Mice, Knockout
-
Murine Acquired Immunodeficiency Syndrome / immunology*
-
Murine Acquired Immunodeficiency Syndrome / physiopathology*
-
Murine Acquired Immunodeficiency Syndrome / virology
-
Proteins / genetics
-
Proteins / immunology
-
Species Specificity
-
Statistics, Nonparametric
Substances
-
Fv1 protein, mouse
-
Interferon Regulatory Factor-3
-
Interferon Regulatory Factor-7
-
Interferon Type I
-
Proteins