Trichodermone, a spiro-cytochalasan with a tetracyclic nucleus (7/5/6/5) skeleton from the plant endophytic fungus Trichoderma gamsii

Gang Ding; Hailou Wang; Li Li; Bo Song; Hong Chen; Hongwu Zhang; Xinzhong Liu; Zhongmei Zou

doi:10.1021/np4007487

Trichodermone, a spiro-cytochalasan with a tetracyclic nucleus (7/5/6/5) skeleton from the plant endophytic fungus Trichoderma gamsii

J Nat Prod. 2014 Jan 24;77(1):164-7. doi: 10.1021/np4007487. Epub 2014 Jan 14.

Authors

Gang Ding¹, Hailou Wang, Li Li, Bo Song, Hong Chen, Hongwu Zhang, Xinzhong Liu, Zhongmei Zou

Affiliation

¹ Institute of Medicinal Plant Development , Beijing, People's Republic of China.

PMID: 24422592
DOI: 10.1021/np4007487

Abstract

Trichodermone (1), the first spiro-cytochalasan with an unprecedented tetracyclic nucleus (7/5/6/5), together with its possible biosynthetic precursor aspochalasin D (2), was isolated from the endophytic fungus Trichoderma gamsii. Compound 2 displayed moderate inhibitory activity against HeLa cells with an IC50 value of 5.72 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Cytochalasins / chemistry
Cytochalasins / isolation & purification
Cytochalasins / pharmacology
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Inhibitory Concentration 50
Molecular Structure
Panax notoginseng / microbiology
Trichoderma / chemistry*

Substances

Antineoplastic Agents
Cytochalasins
aspochalasin D
trichodermone