[Expression of secretoglobin family 2A member 2 in oral lichen planus lesions]

Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Oct;48(10):606-9.
[Article in Chinese]

Abstract

Objective: To examine the expression of secretoglobin family 2A member 2 (SCGB2A2) (mammaglobin A, MGB1) in oral lichen planus (OLP) lesions.

Methods: Sixteen OLP patients and 10 healthy controls were included in this study. The real time reverse transcription-PCR (RT-PCR), Western blotting and immunohistochemistry (IHC) were used to determine the mRNA and protein of SCGB2A2.

Results: Compared with healthy controls (0.48 ± 0.09), the expression of SCGB2A2 protein in OLP lesions significantly increased (1.02 ± 0.11) (P < 0.05).However, the mRNA level of SCGB2A2 in lesions was significantly lower than that in controls (P < 0.05).

Conclusions: These results suggest that SCGB2A2 may be involved in pathogenesis of OLP.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blotting, Western
  • Female
  • Gene Expression Regulation
  • Humans
  • Immunohistochemistry
  • Lichen Planus, Oral / genetics
  • Lichen Planus, Oral / metabolism*
  • Male
  • Mammaglobin A / genetics
  • Mammaglobin A / metabolism*
  • Middle Aged
  • Mouth Mucosa / metabolism*
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Young Adult

Substances

  • Mammaglobin A
  • RNA, Messenger
  • SCGB2A2 protein, human