A serosurvey of severe fever with thrombocytopenia syndrome virus (SFTSV) infection in domestic animals was conducted in the rural areas of Laizhou City, Shandong Province, China to determine strategies for control and prevention of SFTS. Serum samples were collected from cattle, goats, dogs, pigs, and chickens and antibodies against SFTSV were detected by double-antigen sandwich enzyme-linked immunosorbent assay (ELISA). Of 641 serum samples, the SFTSV seropositive rate was 41.8% (268/641): 74.8%, 57.1%, 52.1%, 35.9%, and 0%, for goats, cattle, dogs, chickens, and pigs, respectively. We also found that the SFTSV seropositive rates were high among the aged cattle, goats, dogs, and chickens. SFTSV infections existed among cattle, goats, dogs, and chickens in Laizhou City, and goats had the highest seroprevalence. SFTSV seroprevalence increased with an increase in age among animals. To control of animal infestation with ticks may prevent human SFTSV infections.