Psychiatrists' attitudes toward metabolic adverse events in patients with schizophrenia

PLoS One. 2014 Jan 23;9(1):e86826. doi: 10.1371/journal.pone.0086826. eCollection 2014.

Abstract

Background: There is growing concern about the metabolic abnormalities in patients with schizophrenia.

Aims: The aim of this study was to assess the attitudes of psychiatrists toward metabolic adverse events in patients with schizophrenia.

Method: A BRIEF QUESTIONNAIRE WAS CONSTRUCTED TO COVER THE FOLLOWING BROAD AREAS: the psychiatrists' recognition of the metabolic risk of antipsychotic therapy, pattern of monitoring patients for physical risks, practice pattern for physical risks, and knowledge of metabolic disturbance. In March 2012, the questionnaire was mailed to 8,482 psychiatrists who were working at hospitals belonging to the Japan Psychiatric Hospitals Association.

Results: The overall response rate was 2,583/8,482 (30.5%). Of the respondents, 85.2% (2,200/2,581) reported that they were concerned about prescribing antipsychotics that have a risk of elevating blood sugar; 47.6% (1,201/2,524) stated that their frequency of monitoring patients under antipsychotic treatment was based on their own experiences; and only 20.6% (5,22/2,534) of respondents answered that the frequency with which they monitored their patients was sufficient to reduce the metabolic risks.

Conclusions: Psychiatrists practicing in Japan were generally aware and concerned about the metabolic risks for patients being treated with antipsychotics. Although psychiatrists should monitor their patients for metabolic abnormalities to balance these risks, a limited number of psychiatrists answered that the frequency with which they monitored patients to reduce the metabolic risks was sufficient. Promotion of the best practices of pharmacotherapy and monitoring is needed for psychiatrists treating patients with schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / adverse effects*
  • Attitude of Health Personnel*
  • Awareness*
  • Blood Glucose / analysis
  • Humans
  • Japan
  • Metabolic Syndrome / chemically induced*
  • Practice Patterns, Physicians'*
  • Psychiatry*
  • Risk Factors
  • Schizophrenia / drug therapy*
  • Surveys and Questionnaires

Substances

  • Antipsychotic Agents
  • Blood Glucose

Grants and funding

This work was partially supported by Eisai Co., Ltd., Yoshitomi Pharmaceutical Industries, Ltd., Dainippon Sumitomo Pharma Co., Ltd., Astellas Pharma Inc., Meiji Seika Pharma Co., Ltd., Eli Lilly Japan, K.K., Otsuka Pharmaceutical Co., Ltd., GlaxoSmithKelin K.K., Janssen Pharmaceutical K.K., MSD K.K., Shionogi & Co., Ltd., Asahi Kasei Pharma Corporation, Novartis Pharma Co., Ltd., Takeda Pharmaceutical Co., Ltd., and Tsumura & Co. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.