Whole-Genome Sequencing of the Nonproteolytic Bacillus anthracis V770-NP1-R Strain Reveals Multiple Mutations in Peptidase Loci

Inbar Cohen-Gihon; Ofir Israeli; Adi Beth-Din; Haim Levy; Ofer Cohen; Avigdor Shafferman; Anat Zvi; Theodor Chitlaru

doi:10.1128/genomeA.00075-14

Whole-Genome Sequencing of the Nonproteolytic Bacillus anthracis V770-NP1-R Strain Reveals Multiple Mutations in Peptidase Loci

Genome Announc. 2014 Feb 13;2(1):e00075-14. doi: 10.1128/genomeA.00075-14.

Authors

Inbar Cohen-Gihon¹, Ofir Israeli, Adi Beth-Din, Haim Levy, Ofer Cohen, Avigdor Shafferman, Anat Zvi, Theodor Chitlaru

Affiliation

¹ Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.

Abstract

We report the draft whole-genome sequence of the nonproteolytic Bacillus anthracis V770-NP1-R strain. Compared to those of other B. anthracis strains, the genome exhibits unique mutations in multiple targets potentially affecting proteolytic functions. One of these mutations is a deletion that disrupts the NprR quorum-sensing regulator of the NprA protease.