Pulmonary thromboembolism in lung surgery: use of unfractionated heparin

Asian Cardiovasc Thorac Ann. 2014 Jan;22(1):46-8. doi: 10.1177/0218492313475672. Epub 2013 Oct 22.

Abstract

Background: While thoracic surgeons occasionally encounter pulmonary thromboembolism, the use of unfractionated heparin may cause adverse effects.

Methods: We assessed a series of 323 consecutive pulmonary operations performed during 4 years from 2008 to 2011. All patients were given elastic stockings and intermittent pneumatic compression. During the first 2 years (2008-2009), none of the 169 patients received unfractionated heparin. In the second 2-year period (2010-2011), 135/154 patients received subcutaneous unfractionated heparin, either 5000 units (n = 37) or 2500 units (n = 93) twice daily for 3 days, or continuous intravenous unfractionated heparin (n = 5). The epidural catheters were withdrawn 6 h or more after unfractionated heparin use. Among patients without postoperative unfractionated heparin, 8 (42.1%) had a bleeding risk and 5 (26.3%) had limited operative time.

Results: One (0.6%) patient developed pulmonary thromboembolism during 2008-2009, but none had this complication during 2010-2011. The adverse outcome of intrathoracic bleeding occurred in one (2.7%) of the patients given 5000 units of unfractionated heparin, but no epidural hematomas occurred in these patients.

Conclusion: Patients undergoing thoracic surgery at low risk of bleeding may receive unfractionated heparin to prevent pulmonary thromboembolism while avoiding epidural complications.

Keywords: Anesthesia epidural; Heparin; Intermittent pneumatic compression devices; Pulmonary embolism; Pulmonary surgical procedures; Stockings; compression.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anticoagulants / administration & dosage*
  • Anticoagulants / adverse effects
  • Drug Administration Schedule
  • Female
  • Hemorrhage / chemically induced
  • Heparin / administration & dosage*
  • Heparin / adverse effects
  • Humans
  • Infusions, Intravenous
  • Injections, Subcutaneous
  • Intermittent Pneumatic Compression Devices
  • Male
  • Middle Aged
  • Pulmonary Embolism / diagnosis
  • Pulmonary Embolism / etiology
  • Pulmonary Embolism / prevention & control*
  • Pulmonary Surgical Procedures / adverse effects*
  • Risk Assessment
  • Risk Factors
  • Stockings, Compression
  • Time Factors
  • Treatment Outcome
  • Young Adult

Substances

  • Anticoagulants
  • Heparin