Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo

Adv Healthc Mater. 2014 Sep;3(9):1392-7. doi: 10.1002/adhm.201400054. Epub 2014 Mar 13.

Abstract

New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.

Keywords: gene expression; gene silencing; lipid-like nanomaterials; plasmid DNA; siRNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Gene Expression*
  • Gene Silencing*
  • HeLa Cells
  • Humans
  • Lipids / chemistry*
  • Lipids / pharmacokinetics
  • Mice
  • Mice, Inbred C57BL
  • Nanostructures / chemistry*
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • Transfection / methods*
  • Triazines / chemistry

Substances

  • Lipids
  • RNA, Small Interfering
  • Triazines