ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children

Br J Haematol. 2014 Jun;165(6):836-41. doi: 10.1111/bjh.12834. Epub 2014 Mar 15.

Abstract

We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.

Keywords: ATF7IP; PDGFRB; Ph-like; acute lymphoblastic leukaemia; screening.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Child
  • Chromosome Breakpoints
  • Cluster Analysis
  • Gene Expression Profiling
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Oncogene Proteins, Fusion / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Receptor, Platelet-Derived Growth Factor beta / genetics*
  • Repressor Proteins
  • Transcription Factors / genetics*
  • Translocation, Genetic

Substances

  • ATF7IP protein, human
  • Oncogene Proteins, Fusion
  • Repressor Proteins
  • Transcription Factors
  • Receptor, Platelet-Derived Growth Factor beta