Lack of correlation between blood group and HER-2 status in adenocarcinomas of the upper gastrointestinal tract

Mol Clin Oncol. 2013 Nov;1(6):1079-1083. doi: 10.3892/mco.2013.181. Epub 2013 Sep 12.

Abstract

The assessment of the human epidermal growth factor receptor-2 (HER-2) status has become a routine diagnostic procedure for patients with advanced-stage gastroesophageal adenocarcinoma. The aim of this study was to evaluate the possible correlation between the HER-2 status and the ABO blood group. HER-2 status determination and routine ABO typing was performed according to current standards. We evaluated the correlation between the HER-2 status and the ABO and Rhesus (Rh) system in 100 consecutive patients with adenocarcinoma of the upper gastrointestinal tract. There were no significant differences between HER-2 status and ABO and Rh system. Furthermore, no correlation was observed between the HER-2 status and the ABO and Rh type in patients with adenocarcinoma of the upper gastrointestinal tract.

Keywords: adenocarcinoma; blood group; gastroesophageal cancer; human epidermal growth factor receptor-2 status.