SUMMARY Neuropathic pain is a complex pain syndrome that remains difficult to treat. Patients fail to obtain satisfactory relief despite receiving pharmacological agents. Neuropathic pain has a significant impact on health-related quality of life. A multidisciplinary approach is recommended in the treatment of neuropathic pain. Preventative, nonpharmacological and pharmacological treatments are suggested in the management of neuropathic pain. Interventional options, such as spinal cord stimulation, intrathecal drug delivery, intravenous infusions therapies, and sympathetic nerve block, should be considered in patients with refractory neuropathic pain.