Three clustered cases of candidemia caused by Candida quercitrusa and mycological characteristics of this novel species

J Clin Microbiol. 2014 Aug;52(8):3044-8. doi: 10.1128/JCM.00246-14. Epub 2014 Apr 2.

Abstract

We investigated three nosocomial Candida quercitrusa candidemia cases occurring within 2 months in a Chinese hospital. Isolates were identifiable only by DNA sequencing of the rRNA genes. Genetic (via random amplified polymorphic DNA [RAPD]) and protein mass spectral (via matrix-assisted laser desorption ionization-time of flight mass spectrometry [MALDI-TOF MS]) analyses yielded identical profiles suggesting an outbreak. The fluconazole MICs of all the strains were 16 to 32 μg/ml.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antifungal Agents / pharmacology
  • Candida / chemistry
  • Candida / classification*
  • Candida / genetics
  • Candida / isolation & purification*
  • Candidemia / diagnosis
  • Candidemia / microbiology*
  • China
  • Cross Infection / diagnosis
  • Cross Infection / microbiology*
  • Fluconazole / pharmacology
  • Hospitals
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Sequence Data
  • RNA, Ribosomal / genetics
  • Random Amplified Polymorphic DNA Technique
  • Sequence Analysis, DNA
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

  • Antifungal Agents
  • RNA, Ribosomal
  • Fluconazole

Associated data

  • GENBANK/KF220648
  • GENBANK/KF220649
  • GENBANK/KF220650
  • GENBANK/KF220651
  • GENBANK/KF220652
  • GENBANK/KF220653