Topical amphotericin B in combination with standard therapy for severe necrotizing skin and soft-tissue mucormycosis in an infant with bilineal leukemia: case report and review

J Pediatr Hematol Oncol. 2014 Oct;36(7):e468-70. doi: 10.1097/MPH.0000000000000166.

Abstract

During chemotherapy for bilineal leukemia, a 6-month-old infant presented with a necrotizing skin and soft-tissue infection of the chest wall due to Rhizopus sp. Successful outcome was achieved by systemically administered liposomal amphotericin B and local wound control with the novel administration of topical deoxycholate amphotericin B and surgical resection.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Administration, Topical
  • Amphotericin B / administration & dosage*
  • Antifungal Agents / administration & dosage
  • Antineoplastic Agents / antagonists & inhibitors*
  • Fatal Outcome
  • Humans
  • Infant
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / drug therapy*
  • Male
  • Mucormycosis / complications
  • Mucormycosis / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Rhizopus / drug effects*

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • Amphotericin B