Augmentation of rat liver regeneration by FK 506 compared with cyclosporin

Lancet. 1989 Nov 25;2(8674):1248-9. doi: 10.1016/s0140-6736(89)91853-9.

Abstract

The immunosuppressive drug, FK 506, increased the regeneration response that follows 40% and 70% hepatectomy in rats. The effect was similar to that obtained with cyclosporin.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology*
  • Cyclosporins / administration & dosage
  • Cyclosporins / pharmacology*
  • DNA / biosynthesis
  • Drug Evaluation, Preclinical
  • Hepatectomy
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / pharmacology*
  • Injections, Intramuscular
  • Liver Regeneration / drug effects*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Stimulation, Chemical
  • Tacrolimus

Substances

  • Anti-Bacterial Agents
  • Cyclosporins
  • Immunosuppressive Agents
  • DNA
  • Tacrolimus