The epidemiological features of 298 imported malaria cases during 2008-2012 in Guangzhou were analyzed. Among the cases, 169 (56.7%) were falciparum malaria, 106 (35.6%) were vivax malaria, and 23 (7.7%) were unidentified. The proportion of falciparum malaria cases was raising gradually in the last 5 years. Most of the cases were infected in malaria endemic regions of Africa and South-East Asia. Among them, 160 (53.7%) were business services, 78 (26.2%) were export laborers, 20 (6.7%) were peasants, and 18 (6.0%) were others.