Broad-spectrum antiviral property of polyoxometalate localized on a cell surface

ACS Appl Mater Interfaces. 2014 Jun 25;6(12):9785-9. doi: 10.1021/am502193f. Epub 2014 Jun 6.

Abstract

Cs2K4Na[SiW9Nb3O40] has broad antiviral ability including anti-Influenza A, -Influenza B, -HSV-1, -HSV-2, -HIV-1, and -HBV. A series of antivirus and/or biochemical experiments and X-ray nanotomography analysis confirm that this kind of broad-spectrum antiviral property is mainly due to its localization on the cell surface.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology
  • Hep G2 Cells / chemistry
  • Hep G2 Cells / virology
  • Humans
  • Surface Properties
  • Tungsten Compounds / chemistry*
  • Tungsten Compounds / pharmacology
  • Viruses / drug effects*

Substances

  • Antiviral Agents
  • Tungsten Compounds
  • polyoxometalate I