A moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species

Mol Cell Biol. 1989 May;9(5):2220-3. doi: 10.1128/mcb.9.5.2220-2223.1989.

Abstract

In two distantly related Drosophila species, the use of alternate 5' splice sites to process an intron in pre-mRNA from homologous adenine phosphoribosyltransferase (APRT)-encoding genes led to RNAs encoding nonfunctional peptides in addition to APRT. The production of aberrantly spliced transcripts as a normal feature of gene expression supports a general model of eucaryotic gene evolution through alternative splicing and moveable splice junctions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenine Phosphoribosyltransferase / genetics*
  • Animals
  • Base Sequence
  • Binding Sites
  • Biological Evolution
  • DNA / genetics
  • Drosophila / genetics*
  • Drosophila / metabolism
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / metabolism
  • Introns
  • Molecular Sequence Data
  • Pentosyltransferases / genetics*
  • RNA Precursors / genetics
  • RNA Precursors / metabolism
  • RNA Splicing*
  • Species Specificity

Substances

  • RNA Precursors
  • DNA
  • Pentosyltransferases
  • Adenine Phosphoribosyltransferase

Associated data

  • GENBANK/M26719