Abstract
In two distantly related Drosophila species, the use of alternate 5' splice sites to process an intron in pre-mRNA from homologous adenine phosphoribosyltransferase (APRT)-encoding genes led to RNAs encoding nonfunctional peptides in addition to APRT. The production of aberrantly spliced transcripts as a normal feature of gene expression supports a general model of eucaryotic gene evolution through alternative splicing and moveable splice junctions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenine Phosphoribosyltransferase / genetics*
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Animals
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Base Sequence
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Binding Sites
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Biological Evolution
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DNA / genetics
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Drosophila / genetics*
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Drosophila / metabolism
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Drosophila melanogaster / genetics
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Drosophila melanogaster / metabolism
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Introns
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Molecular Sequence Data
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Pentosyltransferases / genetics*
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RNA Precursors / genetics
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RNA Precursors / metabolism
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RNA Splicing*
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Species Specificity
Substances
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RNA Precursors
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DNA
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Pentosyltransferases
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Adenine Phosphoribosyltransferase