Comparative characteristics of genetic aberrations in glioblastomas in children and adults
Zh Vopr Neirokhir Im N N Burdenko. 2014;78(2):3-11; discussion 11.
[Article in
English,
Russian]
Authors
M V Ryzhova, L V Shishkina, O G Zheludkova, A V Golanov, S K Gorelyshev, D I Pitskhelauri, A Kh Bekiashev, G L Kobiakov, O V Absaliamova, R V Sycheva, A G Korshunov
Abstract
Glioblastomas in children and adults are a heterogeneous group of tumors that can be divided into at least three different subgroups: pediatric glioblastomas, IDH1-mutant glioblastomas in adults (the most favorable prognostic subtype), and IDH1-wild type glioblastomas in adults. According to the frequency of detected cytogenetic aberrations (amplification of the MYC/MYCN, EGFR and PDGRFA oncogenes, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene), pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adolescent
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Adult
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Child
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Child, Preschool
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Chromosome Aberrations*
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Glioblastoma / genetics*
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Glioblastoma / pathology*
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Humans
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Male
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Middle Aged
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Neoplasm Proteins / genetics*