Time resolved analysis of quetiapine and 7-OH-quetiapine in hair using LC/MS-MS

Forensic Sci Int. 2014 Sep:242:200-203. doi: 10.1016/j.forsciint.2014.07.002. Epub 2014 Jul 11.

Abstract

Hair analysis is a powerful tool for retrospective drug analysis and has a wide application window. This article describes the simultaneous determination and quantification of the short-acting atypical antipsychotic drug quetiapine and its main metabolite 7-OH quetiapine in hair. A sensitive and accurate method for the determination of these two compounds was developed using high-performance liquid chromatography coupled to tandem mass spectrometry detection (LC-MS/MS). The method was applied to 10 real case samples. For five patients, a time resolved hair analysis was done. Results varied from 0.35 ng/mg to 10.21 ng/mg hair for quetiapine and from 0.02 ng/mg to 3.19 ng/mg hair for 7-OH-quetiapine.

Keywords: 7-OH-quetiapine; Antipsychotics; Hair analysis; LC–MS/MS; Quetiapine.

MeSH terms

  • Adult
  • Antipsychotic Agents / analysis*
  • Chromatography, Liquid
  • Dibenzothiazepines / analysis*
  • Female
  • Hair / chemistry*
  • Humans
  • Limit of Detection
  • Male
  • Middle Aged
  • Quetiapine Fumarate
  • Tandem Mass Spectrometry
  • Time Factors

Substances

  • Antipsychotic Agents
  • Dibenzothiazepines
  • Quetiapine Fumarate