Testosterone deficiency and quality of life in Australasian testicular cancer survivors: a prospective cohort study

Intern Med J. 2014 Aug;44(8):813-7. doi: 10.1111/imj.12500.

Abstract

This is the first prospective study in a contemporary Australian/New Zealand population to determine the prevalence of testosterone deficiency in testicular cancer survivors at 12 months from treatment, and any association with poorer quality of life. Hormone assays from 54 evaluable patients in a prospective cohort study revealed biochemical hypogonadism in 18 patients (33%) and low-normal testosterone in 13 patients (24%). We found no association between testosterone levels and quality of life (all P > 0.05). Hypogonadal patients should be considered for testosterone replacement to prevent long-term morbidity.

Keywords: hypogonadism; quality of life; testicular cancer.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Australia / epidemiology
  • Follow-Up Studies
  • Hormone Replacement Therapy / methods*
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Germ Cell and Embryonal / blood*
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Neoplasms, Germ Cell and Embryonal / epidemiology
  • New Zealand / epidemiology
  • Prevalence
  • Prospective Studies
  • Quality of Life*
  • Survival Rate / trends
  • Survivors
  • Testicular Neoplasms / blood*
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / epidemiology
  • Testosterone / deficiency*
  • Young Adult

Substances

  • Testosterone

Supplementary concepts

  • Testicular Germ Cell Tumor