Immune-based interventions to prevent postnatal HIV-1 transmission

Genevieve G Fouda; Sallie R Permar

doi:10.1016/j.tim.2014.04.009

Immune-based interventions to prevent postnatal HIV-1 transmission

Trends Microbiol. 2014 Aug;22(8):425-7. doi: 10.1016/j.tim.2014.04.009.

Authors

Genevieve G Fouda¹, Sallie R Permar²

Affiliations

¹ Department of Pediatrics and Human Vaccine Institute, Duke University Medical Center, Durham, NC 27705, USA.
² Department of Pediatrics and Human Vaccine Institute, Duke University Medical Center, Durham, NC 27705, USA. Electronic address: sallie.permar@duke.edu.

PMID: 25086471
DOI: 10.1016/j.tim.2014.04.009

Abstract

Despite global scale-up in antiretroviral-based prevention of mother-to-child transmission services, more than 250 000 infants become infected with HIV-1 each year. Breast milk transmission is responsible for almost half of these infections. The development of alternative strategies to prevent postnatal HIV-1 transmission is imperative to achieve a generation free of HIV-1.

MeSH terms

AIDS Vaccines / administration & dosage
HIV Antibodies / therapeutic use*
HIV Infections / prevention & control*
HIV Infections / transmission
HIV-1 / immunology*
Humans
Immunity, Maternally-Acquired
Infectious Disease Transmission, Vertical / prevention & control*
Postnatal Care / methods*

Substances

AIDS Vaccines
HIV Antibodies