Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus

Cynthia L Courtney; Kelly F Ethun; Francois Villinger; Ruth M Ruprecht; Siddappa N Byrareddy

doi:10.1111/jmp.12142

Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus

J Med Primatol. 2015 Feb;44(1):35-9. doi: 10.1111/jmp.12142. Epub 2014 Sep 1.

Authors

Cynthia L Courtney¹, Kelly F Ethun, Francois Villinger, Ruth M Ruprecht, Siddappa N Byrareddy

Affiliation

¹ Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Pathology & Laboratory Medicine, School of Medicine and Emory Vaccine Center, Emory University, Atlanta, GA, USA.

Abstract

Background: Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection.

Methods and results: Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals.

Conclusion: This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.

Keywords: SHIV; SIV; pulmonary arterial hypertension.

Publication types

Case Reports
Research Support, N.I.H., Extramural

MeSH terms

Animals
Animals, Laboratory*
Fatal Outcome
Hypertension, Pulmonary / virology*
Macaca nemestrina*
Male
Monkey Diseases / virology*
Pulmonary Artery / pathology*
Simian Acquired Immunodeficiency Syndrome / complications*
Simian Immunodeficiency Virus / physiology
Thrombosis / virology*

Abstract

Publication types

MeSH terms

Grants and funding