The structural and functional coordination of glycolytic enzymes in muscle: evidence of a metabolon?

Lynda Menard; David Maughan; Jim Vigoreaux

doi:10.3390/biology3030623

The structural and functional coordination of glycolytic enzymes in muscle: evidence of a metabolon?

Biology (Basel). 2014 Sep 22;3(3):623-44. doi: 10.3390/biology3030623.

Authors

Lynda Menard¹, David Maughan², Jim Vigoreaux³

Affiliations

¹ Department of Biology, University of Vermont, Burlington, VT 05405, USA. lmmenard@uvm.edu.
² Department of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA. dmaughan@uvm.edu.
³ Department of Biology, University of Vermont, Burlington, VT 05405, USA. dmaughan@uvm.edu.

Abstract

Metabolism sustains life through enzyme-catalyzed chemical reactions within the cells of all organisms. The coupling of catalytic function to the structural organization of enzymes contributes to the kinetic optimization important to tissue-specific and whole-body function. This coupling is of paramount importance in the role that muscle plays in the success of Animalia. The structure and function of glycolytic enzyme complexes in anaerobic metabolism have long been regarded as a major regulatory element necessary for muscle activity and whole-body homeostasis. While the details of this complex remain to be elucidated through in vivo studies, this review will touch on recent studies that suggest the existence of such a complex and its structure. A potential model for glycolytic complexes and related subcomplexes is introduced.

Publication types

Review