Abstract
The aim of this study was to elucidate whether glutathione is involved in lithium's ability to decrease carbonylation and nitration produced by complex I inhibition, which is consistently found in BD. Neuroblastoma cells were treated with rotenone, a complex I inhibitor. Our results suggest that glutathione is essential for lithium's ability to ameliorate rotenone-induced protein carbonylation, but not nitration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cell Survival / drug effects
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Cell Survival / physiology
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Electron Transport Complex I / antagonists & inhibitors*
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Glutathione / metabolism*
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Humans
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Immunohistochemistry
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Lithium Compounds / pharmacology*
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Neuroblastoma / metabolism
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Protein Carbonylation / drug effects*
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Rotenone / pharmacology
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Tyrosine / analogs & derivatives*
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Tyrosine / metabolism
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Uncoupling Agents / pharmacology
Substances
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Lithium Compounds
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Uncoupling Agents
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Rotenone
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3-nitrotyrosine
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Tyrosine
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Electron Transport Complex I
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Glutathione