Abstract
Transgenic technology allows the introduction into the germline of an animal of a known gene coding for a normally foreign antigen, and by means of a specific promoter, the direction of its expression to specific tissues. The antigen is therefore synthesized by the animal as an authentic self molecule, at a particular stage in development, and in a particular site. In this review, J.F.A.P. Miller and colleagues discuss this radically new approach to the investigation of the mechanism of acquired immunological tolerance to self components.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, Polyomavirus Transforming / genetics
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Antigens, Polyomavirus Transforming / immunology
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Gene Expression Regulation
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Histocompatibility Antigens / genetics
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Histocompatibility Antigens / immunology
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Immune Tolerance*
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Immunoglobulins / genetics
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Immunoglobulins / immunology
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Islets of Langerhans / immunology
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Lymphocytes / immunology
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Mice
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Mice, Transgenic / immunology
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Organ Specificity
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Promoter Regions, Genetic
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Receptors, Antigen, T-Cell / genetics
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Receptors, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell, alpha-beta
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Recombinant Fusion Proteins / biosynthesis
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Recombinant Fusion Proteins / immunology*
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Recombinant Proteins / immunology*
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Thymus Gland / immunology
Substances
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Antigens, Polyomavirus Transforming
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Histocompatibility Antigens
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Immunoglobulins
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Receptors, Antigen, T-Cell
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Receptors, Antigen, T-Cell, alpha-beta
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Recombinant Fusion Proteins
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Recombinant Proteins